Epilepsy and GABA Receptor Agonists Basic and Therapeutic Research
نویسندگان
چکیده
منابع مشابه
GABA(A) receptor epilepsy mutations.
Idiopathic generalized epilepsy (IGE) syndromes are diseases that are characterized by absence, myoclonic, and/or primary generalized tonic-clonic seizures in the absence of structural brain abnormalities. Although it was long hypothesized that IGE had a genetic basis, only recently have causative genes been identified. Here we review mutations in the GABA(A) receptor alpha1, gamma2, and delta ...
متن کاملGABA signaling regulation by GLP-1 receptor agonists and GABA-A receptors modulator
Babateen, O. M. 2016. GABA signaling regulation by GLP-1 receptor agonists and GABAA receptors modulator. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1209. 51 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9548-0. GABA (γ-aminobutyric acid) is the main neuroinhibitory transmitter in mammalian brains. It binds to GABA-A and GABA-B receptors...
متن کامل5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.
In vitro, (S)-2-(chloro-5-fluoro-indol-1-yl)-1-methylethylamine 1:1 C4H4O4 and (S)-2-(4,4,7-trimethyl-1,4-dihydro-indeno[1, 2-b]pyrrol-1-yl)-1-methylethylamine 1:1 C4H4O4 exhibited high-affinity binding to the serotonin2C (5HT2C) receptors and stimulated turnover of inositol 1,4,5-triphosphate. Affinity to several of the other 5-HT receptor subtypes and to numerous nonserotonergic receptors was...
متن کاملBiology and therapeutic potential of cannabinoid CB2 receptor inverse agonists.
Evidence has emerged suggesting a role for the cannabinoid CB2 receptor in immune cell motility. This provides a rationale for a novel and generalized immunoregulatory role for cannabinoid CB2 receptor-specific compounds. In support of this possibility, we will review the biology of a class of cannabinoid CB2 receptor-specific inverse agonist, the triaryl bis-sulfones. We will show that one can...
متن کاملEffect of GABA agonists and GABA-A receptor modulators on cocaine- and food-maintained responding and cocaine discrimination in rats.
Recent studies indicate that GABAergic ligands modulate abuse-related effects of cocaine. The goal of this study was to evaluate the effects of a mechanistically diverse group of GABAergic ligands on the discriminative stimulus and reinforcing effects of cocaine in rats. One group of rats was trained to discriminate 5.6 mg/kg cocaine from saline in a two-lever, food-reinforced, drug discriminat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1986
ISSN: 0022-3050
DOI: 10.1136/jnnp.49.6.731